The Effect of Eight-Week Resistance and Aerobic Training on Lipid Profile and Serum Levels of Hepatokine HFREP1 in Obese Men with Type 2 Diabetes

The prevalence of overweight and obesity has increased diabetes around the world. Previous researches emphasized the effect of regular training in increasing insulin sensitivity and improving glucose metabolism. However, the purpose of this study was to investigate the effect of eight-week resistance and aerobic training on lipid profile and serum levels of hepatokine HFREP1 in obese men with type 2 diabetes. 34 participants with type 2 diabetes were randomly assigned to three groups of aerobic training (BMI 33.40± 3.33 kg/m2, age of 52.41± 1.83), resistance (BMI 31.20± 1.20 kg/m2, age of 52.45± 1.5) groups and a control group (BMI 32.60± 2.88 kg/m2, age of 53.09± 1.13). The experimental groups did eight-week aerobic and resistance training. In this study HFREP1, FBS, HbA1c, HOMA-IR, triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were measured before and after the training period by applying ELISA test, HPLC, and Enzyme photometric. Then, assigning the normality through Shapiro-Wilk test, ANCOVA test and Bonferroni test were applied to compare data between three groups. Furthermore, the significant level for analyzing data was p˂0.05. Also, in all factors except TC, HOMA-IR, HDL, and LDL there was a significant difference between resistance and endurance groups (p˂0.05). resistance and aerobic training had a significant effect on Insulin resistance and lipid profile; and eight-week resistance and aerobic training lead to decreasing in HFREP1, FBS, HbA1c, HOMA-IR, TG, and LDL while HDL increased. Although resistance and aerobic training have an effect on Insulin resistance and lipid profile, it seems that the effect of resistance training on above-mentioned variables is superior.