A Survey on the Effects of Intravenous Tranexamic Acid on the Amount of Transfusion in Patients Undergoing T.U.R-P

Perioperative blood loss is thought to be associated with an increase in urinary fibrinolytic activity. Tranexamicacid (TXA) is a potent inhibitor of plasminogen and also urokinase activators. To determine the efficacy of preoperative treatment with tranexamic acid in the rate of perioperativetransfusions in patients undergoing transurethral resection of the prostate(TURP). In a clinical trial, 80 patients were randomly divided into two groups: Tranexamic acid (TXA) and controls. After Spinal anesthesia with marcaine, in the Tranexamic acid group (TXA), the patients received intravenous infusion of tranexamic acid15 mg/kg before surgery and the control group received no medication, and serum Hb concentration was measured 1 hour after beginning the surgery, in recovery room, and 6 hours and 24 hours after surgery. If the hemoglobin concentration was lower than 10 mg/dL, one or more units of allogeneic packed red blood cells were transfused to keep the concentration of hemoglobin above 10 mg/dL, finally the mean need for the erythrocyte transfusions was compared between two groups. We used statistical tests such as T-test,Repeated Measurement, ANCOVATest and SPSS software 16. P values less than 0.05 were considered significant. This study, showed that the mean perioperative blood transfusion 24 hours post operation, in TXA group was less than that in control group (0.2±0.6)vs(0.6 ±0.92).(P=0.026) preoperative treatment with tranexamic acid reduces the rate of perioperative blood transfusions in patients undergoing T.U.R-P.