Central Diabetes Insipidus Outcome in Neurosurgical Patients Admitted to Intensive Care

Central Diabetes Insipidus is caused by the reduction or lack of production of antidiuretic hormone in neurohypophysis, which has many causes. The aim of this study was to determine the frequency and outcome of diabetes Insipidus in operated neurosurgical patients admitted to the intensive care unit of Imam Khomeini in a 5-year period (1393-1393). This cross-sectional study was conducted in a period of 5 years. Patients' demographic information (age, sex), underlying disease, surgical agent, insignificant diabetes, duration of mechanical ventilation, length of hospitalization in intensive care unit, mortality of patients were extracted from files and entered into a researcher-made form. SPSS 21 was used for analyzing the data. P <0.05 was considered significant. Of 741 patients, 135 (18.2%) had central diabetes insipidus and 606 (81.8%) were without it. The mean of S.G. urinary tract in patients with diabetes insipidus was 1003.86 ± 4.35 and in non-diabetic patients was 1015.76 ± 13.35 (P <0.05). The mean serum sodium level in patients with diabetes insipidus was 152.69 ± 4.96 and in non-diabetic patients was 139.26 ± 3.61 (P <0.05). The mean urinary output level in patients with central diabetes insipidus was 12.44 ± 12.127-12.127 and in non-central diabetic patients was 97.58 ± 587.186 (P <0.05). Of 135 patients with diabetes insipidus, 72 (53.3%) discharged and 63 (46.7%) died. Of 606 patients without diabetes insipidus, 455 (75.1%) discharged and 151 (24.9%) died (P <0.05). The results of this study show that patients with central diabetes insipidus have a poor outcome after brain surgery in comparing with patients without the disease.