Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone Fractures

Non::union:: of bone fracture is a clinical and treatment challenge. Satisfactory repair of orthopedic fractures is of great importance and systemic treatment is used to achieve this goal. This study aimed to investigate the effect of Teriparatide (CinnoPar®) on non::union:: fractures. A quasi-experimental study was conducted in 17 patients with non::union:: bone fractures. Radiographic evaluation was performed before the intervention and non::union:: was confirmed by a radiologist. Then, all patients received Teriparatide for three months. Afterwards, a control x-ray image was taken to assess the outcome. Sixteen patients (mean age: 45.18±20.51) with non::union:: fracture were evaluated, including nine males and seven females. The mean time after the accident was 50 ±24.48 weeks. Femoral bone was the most reported impaired site (n=8). After treatment with Teriparatide (CinnoPar®) improvements were seen in 10 patients (P= 0.002).  Treatment with CinnoPar® was found to be effective to some extent. However, due to the small sample size in this study, the efficacy of CinnoPar® needs further assessments.