The effect of progressive resistance training with melatonin supplementation on total antioxidant capacity and lipid peroxidation in overweight men, randomized clinical trial

The purpose of present study was to investigate the effect of progressive resistance training with melatonin supplementation on plasma total antioxidant capacity and lipid peroxidation in overweight men. In this clinical trial, 40 men with body mass index (BMI) between 25-30 were randomly divided into into four groups: training-supplement (N=10), training-placebo (N=10), supplement (N=10), and placebo (N=10). The training group performed an progressive resistance training session, 3 sessions each week with 55-85% 1RM for 8 weeks. The treatment groups received three mg of melatonin in capsule form every day two hours before bedtime. Data were statistically analyzed by ANCOVA and post-hoc Bonferroni methods (p≤0.05). The results showed that resistance training with melatonin consumption significantly increased TAC in training-supplement (p≤0.007), training-placebo (p≤0.029), supplement (p≤0.025) groups. However, significantly increased MDA values only in training-supplement (p≤0.039) and supplement (p≤0.048) groups.However, no significant changes were observed in the training-placebo and control groups (P> 0.05). The results of the intergroup differences indicated that TAC was significant only between the training-supplement, training-placebo and control groups (p≤0.05). groups. While there was no significant difference in MDA values between the training-supplement, training-placebo, supplement and placebo groups (P> 0.05). Supplementation of melatonin alone and in combination with resistance training has been more effective due to potent antioxidant anti-inflammatory effects, can would improve the antioxidant capacity in overweight men.