Effect of 6 Weeks High Intensity Interval Training on Selected Factors of Cardiac Angiogenesis in Rats with Myocardial Infarction

Myocardial infarction (MI) is cell death in part of the myocardial during an Ischemia. Cell process in response to activity and appropriate intensity is not clear yet. Therefore, this research done to evaluate the effect of 6 weeks high intensity interval training (HIIT) on expression of VEGF, COL-18 and their common receptor (Flt-1) genes. For this purpose, 12 Wistar male rats with 10 weeks old and average weight 250-300 gr that infected to myocardial infarction and they were designed in to two groups of experimental (60 minutes of interval running on treadmills that each interval is 4 minutes with the 85-90 percent of Vo2max and 2 minutes of active rest at 50-60 percent of Vo2max for four days in a week and during a period of 6 weeks) and control group (without any training) . Genes expression was investigated by the PCR technique and data were analyzed by the SPSS 18 with T test (α≤0.05). The findings of present study showed that the amount of VEGF in HIIT (6.397 mg/ml) is significantly much more than the control group (1.002 mg/ml) (P=0.001) and the amount of Flt-1 in HIIT group (8.927 mg/ml) was also significantly much more than control group (1.380 mg/ml) (P≤0.001) . and the amount of COL-18 in HIIT group (1.724 mg/ml) was not significantly more than control group (1.265 mg/ml) (P≤0.340). In general, 6 weeks of HIIT can effective on angiogenesis factors after MI in male Wistar rats.