Women with Autoimmune Thyroiditis have Lower Reproductive Life Span or Not? A Cross- Sectional Study

Autoimmune diseases are a main cause of primary ovarian insufficiency. This study wasdesigned to elucidate the relationship between ovarian reserve and anti-thyroid peroxidase antibodiesin women of different ages.

98 women in a cross-sectional study was conducted at the infertility Center of ShirazUniversity of Medical Sciences, Hazrate Zeinab Hospital, from September 2018 to March 2019. Womenwith infertility and thyroid-stimulating hormone (TSH) > 3mIU/L were included in the study withconvenience sampling. Data were collected by a form containing demographic characteristics, thyroidhormones, and ovarian reserve data. Participants were categorized based on the negative or positiveanti-thyroid peroxidase (anti-TPO) antibodies. According to a pilot sample, and possible dropout of20%, the sample size was determined to be 49 cases in each group. The results were compared betweengroups using SPSS, version 22. All statistical comparisons were performed using the t-test, and thedata are presented as the mean±SD. P-values less than 0.05 were considered significant.

49 women were analyzed in each group. There was no significant difference between thegroups in the mean age (P=0.42), body mass index (BMI) (P=0.34), duration of infertility (P=0.99),mean prolactin (P=0.66), TSH (P=0.17), thyroxine (T4) (P=0.87) and follicle-stimulating hormone(FSH) levels (P=0.14). Ovarian reserve characteristics: antral follicular count (AFC) and anti-Müllerianhormone (AMH) levels in anti-TPO positive group were 10.61±7.29 and 1.98±2.38, respectively, andAFC and AMH in anti- TPO negative group were 16.46±6.38 and 2.94±2.22, respectively. There weresignificant differences between the two groups on AFC (P <0.001) and AMH (P=0.04).

Patients with autoimmune thyroiditis were at higher risk for decreased ovarian reserve.They should consider their lower reproductive life span during their childbearing years.