Evaluation of IFN-Gamma and HSP70 Level in the Saliva of Behcet’s Disease Patients With Active Oral Lesions

Behcet’s disease (BD) is a multi-systemic inflammatory disorder. Evaluating theproduction of cytokines such as interferon gamma,biomarkers such as heat shock protein-70(HSP70)is an important way to study the pathogenesis,development of BD. This study aimed tocompare the salivary level of interferon gamma,HSP70 between patients infected with BD andhealthy individual.

This case-control study was performed on 35 patients with Behcet’s syndrome,70 healthyindividuals as the control group,who were selected from those referring to the Department of OralMedicine of Tabriz University of Medical Sciences. The levels of interferon gamma,HSP70 weremeasured in the whole unstimulated saliva through enzyme-linked immunosorbent assay (ELIZA). Inorder to compare the quantitative variables between two groups,independent samples t-test or itsnonparametric equivalent,Mann-Whitney U test,was used in SPSS software version 16.0. In this study,a P value less than 0.05 was considered statistically significant.

There was no significant difference between the study groups in terms of age,gender,aswell as salivary interferon gamma,HSP70 levels. Interferon gamma level was 15.16±3.38 pg,mg inthe case group,5.27±1.21 pg,mg in the control group,and salivary HSP70 level was found to be45.50±17 ng,mL,19.5±5.2 ng,mL in the case,control groups,respectively.

The results of this study showed that interferon gamma,HSP70 levels in patients withBehcet’s syndrome are high,can be evaluated as an important tool for the treatment,evaluationof disease development in future studies