Survey on the Effects of 4-week of the Special Aerobic Training on Hydrogen sulfide Levels in Hippocampus of Wistar Male Rats

Hydrogen sulfide an important role in the body's physiological functions. The aim of the present study was to survey on the effects of 4-week of the special aerobic training on CBS, SAM and H2S levels in hippocampus of Wistar male rats.

Fourteen male Wistar rats (12 weeks old and weight 195 ± 20 g) were randomly divided into two groups including: control and aerobic training. Training group trained 5 days a week for 4 weeks (15 minutes at 10 m/min). ). CBS and SAM mRNA expression in hippocampus was measured by Real time-PCR techniqiue and the ELISA method was used to measure H2S. For data analysis, MANOVA and Eta and Omega squared tests were used to determine the effect size at 95% confidence level (p<0.05).

Findings revealed that the 4-week of special aerobic training increased significantly the CBS, SAM and H2S levels in hippocampus of training rats compared to the control rats ( ES=68.15; P= 0.002, ES= 84.85; P= 0.001, ES= 77.32; P= 0.001).

According to the results, It seems that the special aerobic training can play an important role in physiological and pathophysiological functions through positive regulation of hydrogen sulfide via CBS and SAM enzymes and as a non-pharmacologically beneficial therapeutic treatment for dementia patients.