Effects of Strenuous Endurance and High-Intensity Interval Training on Thioredoxin Reductase-1 Enzyme and Malondialdehyde in Hippocampal Tissue

free radicals cause more than 60 diseases; however, antioxidants can stop the harmful processes induced by free radicals in the body. In this regard, the present study aimed to investigate the effect of 8 weeks of strenuous endurance training (ET) and high-intensity interval training (HT) on thioredoxin reductase-1 (TRX1) and malondialdehyde (MDA) in hippocampal tissue in male Wistar rats.

In this experimental study, 24 male Wistar rats were randomly divided into three groups of control, ET, and HT. The training protocols consisted of ET and HT on a treadmill for 8 weeks (5 days a week) and the hippocampal tissue samples were collected 48 h after the last session of training. Tissue concentration of TRX1 was measured by ELISA method and MDA concentration was measured by Thiobarbituric acid. Finally, the collected data were analyzed using the one-way analysis of variance.

Based on the results, after 8 weeks, there were no significant differences in the TRX1 level in hippocampal tissue in ET and HT groups compared to the control group (P=0.62). Moreover, after 8 weeks, there were no significant differences in the TRX1 level in hippocampal tissue in ET and HT groups in comparison to the control group (P=0.83).

In conclusion, 8 weeks of ET and HT did not affect the TRX1 and TRX1 level in hippocampal tissue in male Wistar rats.