Effect of chewing gum containing CPP-ACP on salivary concentration of calcium , phosphate and alkaline phosphatase in 7-11 years old children with severe caries

Tooth structure is exposed to continuous demineralization and remineralization in mouth. Balance between demineralization and remineralization depends on salivary concentration of calcium, phosphate and alkaline phosphatase. The aim of this study was to investigate the effect of chewing gum containing CPP-ACP on salivary concentration of calcium, phosphate and alkaline phosphatase in 7-11 years old children with severe caries.

In this analytical-descriptive study, 64 students through randomized sampling were chosen and divided into 2 groups of caries free and severe caries. Three saliva samples were gathered from participants, two hours after breakfast, 5 and 20 minutes after chewing of CPP-ACP gum. The samples were sent to laboratories were analyzed to find calcium, phosphate and alkaline phosphatase content. Data analysis was done by using the paired sample t-test, independent sample t-test at significance level (p value = 0.05) and the SPSS software, version 22.

The average concentration of salivary calcium in both groups caries free and severe caries of the participants, in the two time intervals after chewing gum, 5 and 20 minutes significantly increased (p value < 0.05). The average concentration of Salivary phosphate and alkaline phosphatase in both groups of 5 and 20 minutes, significantly decreased (p value < 0.05).

Chewing gum containing CPP-ACP can remineralized the tooth by increasing calcium and decreasing phosphate and alkaline phosphatase.