High level serum Inhibin-A in 1st and 2th pregnancy trimesters as a risk factor for adverse pregnancy outcomes: a systematic review and meta-analysis

Naturaly; Inhibin-A plays an important role in the reproduction, and its abnormal level can be associated with the risk of adverse pregnancy outcomes. The aim of the current study was to evaluate the effect of high level serum Inhibin-A in the first and second pregnancy trimesters on adverse pregnancy outcomes doing a systematic review and meta-analysis.

In a systematic search done in Pubmed, Embase, Magiran, Irandoc, Web of Science, Scopus, and Google Scholar in Persian and English languages since year 2000, seven articles were extracted and entered in the meta-analysis. Finally, odds ratio and confidence intervale were reported.

The current meta-analysis showed that high level of Inhibin-A incresed the odds of preclampsia (OR= 9.77, 95% C.I: 3.88-24.62); however, it did not affect on cesarean section delivery (OR= 1.06, 95% C.I: 0.80-1.41). As adverse pregnancy outcomes addressing  the fetus and new born, high level of serum inhibin A incresed the odds of low birth weight (OR=7.34, 95% C.I: 4.4-12.23), preterm birth (OR=5.18, 95% C.I: 1.89-14.17), and fetal growth retardation (OR=2.77, 95% C.I: 1.78-4.30).

High level serum Inhibin-A in the first and second pregnancy trimesters increases the odds of preeclampsia, preterm birth, fetal growth retardation, and low birth weight; however, it does not effect on cesarean section.