The Effect of Combined Aerobic- Resistance Exercise Training on Serum Concentrations of CTRP3 and Interleukin-6 in Men with Type 2 Diabetes

Studies have shown that CTRP3, as an insulin-independent anti-inflammatory adipokine, affects metabolism and regulates glucose metabolism. The aim of this study was to investigate the effect of combined aerobic- resistance training on serum concentrations of CTRP3 and interleukin-6 in men with type 2 diabetes.

In this quasi-experimental study, 24 male patients with type 2 diabetes were randomly divided into two groups of combined resistance aerobic exercise (n = 12) and control (n = 12). The subjects of the training group performed combined aerobic- resistance exercises 3 sessions per week for 12 weeks. Before and after 12 weeks of exercise program, blood samples were taken to measure the concentration of CTRP3 and interleukin-6 and anthropometric measurements of the subjects. Analysis of covariance was used to analyze the data.

After 12 weeks in the exercise group, fasting glucose (P = 0.014), HbA1c (P = 0.001), body weight (P = 0.048), body mass index (P = 0.037), body fat percentage (P = 0.001), fat mass (P = 0.001) were significantly decreased compared to the control group, but there was a significant difference in insulin (P = 0.054), lean mass (P = 0.987) and WHR (P = 0.291) between the two groups. After 12 weeks, the concentration of CTRP3 (P = 0.040) in the training group increased and IL-6 (P = 0.028) concentration decreased significantly compared to the control group.

12 weeks of combined aerobic- resistance training in men with type 2 diabetes in addition to glycemic control leads to a significant increase in CTRP3 and a significant decrease in interleukin-6.