The effect of aerobic exercise on liver enzymes and lipid profile in epileptic rats with Pentylenetetrazole

There has been no report on the effect of epilepsy on liver enzymes and lipoproteins and its changes following exercisetraining in epileptic rats with Pentylenetetrazole.

In this experimental study, 70 male rats were placed in 7 groups. An intact group, three groups of Kindle and three groups of non-Kindle who received PTZ or normal saline injections every 48 hours until the animals were kindled. 24 hours after Kindling, blood samples were collected in intact group and two groups of Kindle and non-Kindle. One Kindle group and one non-Kindle group from the remaining four groups performed aerobic exercise for six weeks, and the other two groups were inactive for six weeks. Blood were collected 24 hours after the 6-week period, and were compared with control groups.

After 4 weeks of Kindling period, total cholesterol, triglycerides, low-density lipoprotein, liver enzymes (P <0.001) and antigenic coefficient (P <0.01) increased significantly in the epileptic group. After six weeks of aerobic exercise in Kindle animals; Triglycerides (P <0.001), liver enzymes (P <0.01) and antigenic coefficients significantly reduced, and high-density lipoprotein significantly increased (P <0.01).

The results showed that aerobic exercise in epileptic rats with Pentylenetetrazole improved lipid profile impairement and increased liver enzymes caused by epilepsy.