Evolution of susceptible and resistance of human infectious bacteria and identification of bioactive compounds from Pistacia atlantica, Cassia absus, and Quercucs persica

Ethnomedicinal plants are used to produce of antimicrobial drugs in pharmaceutical industry.

The aim of this study was to identify phytochemical compounds of seed extract from ethnomedicinal plants Pistacia atlantica, Cassia absus and Quercucs persica by GC/MS and investigation of antibacterial and antioxidant activities.

The samples were collected from Lorestan province, Iran. Antibacterial and anti-radical activities were analyzed by Disc-diffusion and DPPH assays, respectively. Ethanol (96%), methanol (80%) and distilled water extracts were obtained by soxhlet. The methanol extract was used to analyses of chemical compositions.

A number of 40, 31 and 8 compounds were identified by GC/MS in seeds of Cassia absus, Pistacia atlantica and Quercucs persica, respectively. Results indicated that 2,4-Di-tert-butylphenol (36.043%) and Tetradecanoic acid (4.92%), were dominated in seed extracts of Cassia absus. However, Germacyclopetene (38.119%) and1,2,3-Benzenetriol (8.115%), were dominated in  seed extracts of Pistacia atlantica. Furthermore, 5H-Tetrazole-5-thione, 1,4-dihydro-1,4-dimethy (38.505%) and Tetradecanoic acid (30.546%), were dominated in  seed extracts of  Quercucs persica. The strongest radical scavenging activity and the highest inhibitory activity against M. luteus were observed on the methanol extract of C. absus. Significant difference between the IC50 values of methanol extract of C. absus compared with ascorbic acid was observed.

Due to the presence of antimicrobial compounds from tested ethnomedicinal plants are suggested to use in pharmaceutical and medical industry.