Evaluation of dosT Gene in Patients with Mycobacterium Tuberculosis

Mycobacterium tuberculosis is a pathogen that can cause tuberculosis in the host. Although Mycobacterium tuberculosis is the oldest known bacterium in humans, it is still a deadly disease worldwide. Mycobacterium tuberculosis can survive in the human body for decades without any symptoms. However, it may be activated in people with defective immune systems or people with diseases such as diabetes, AIDS or malnutrition, leading to tuberculosis. The aim of this study was to evaluate the dosT gene in patients with Mycobacterium tuberculosis The presence of dosT gene in patients with Mycobacterium tuberculosis was determined by PCR and the presence of this gene in susceptible and resistant samples of Mycobacterium tuberculosis was analyzed by many statistical methods. The dosT gene was detected in all patients with E. coli by PCR (219 bp). The frequency of dosT gene in isolates of patients with Mycobacterium tuberculosis was determined (94.3%). The percentage of dosT gene presence in patients with susceptible and resistant Mycobacterium tuberculosis was determined (78.8% and 21.2% in patients with recessive tuberculosis) The presence of dosT gene was detected in almost all patients with Mycobacterium tuberculosis and it was shown that this gene is more common in susceptible isolates of Mycobacterium tuberculosis.