Factors Related to Mortality in Patients with Fournier’sGangrene or Necrotising Fasciitis;a 10-year Cross-Sectional Study

Fournier’s gangrene (FG) is a life-threatening disease, even with early diagnosis and administra-tion of vigorous treatment, its mortality rate is high. This study aimed to evaluate the factors relate to mortalityin patients with FG or necrotising fasciitis managed in a referral center.

This retrospective cross-sectional study was conducted on patients managed in a tertiary referral center, Tehran, Iran, from March 2009to March 2019, with diagnosis of FG or necrotising fasciitis. The correlation between different demographic andclinical parameters with mortality was analysed and reported.

73 cases with the mean age of 59.1 ± 15.8(range: 25 – 88) years were studied (87.7% male). 21 (28.8%) patients died. Escherichia coli (26 cases, 35.6%)was the most frequent microorganism in cultures. Non-survived cases had higher mean age (p = 0.01), higherfrequency of hyperlipidaemia (p = 0.02), immunosuppression (p < 0.001), longer hospital stay (p=0.02), lowerblood pressure (p=0.01), and lower platelet count (p=<0.001). Based on multivariate analysis, age (p = 0.015;Odds: 0.88 (0.79-0.97)), haematocrit level (p = 0.01; Odds: 1.27 (1.04-1.55)), platelet count (p = 0.03; Odds: 10.11(1.14-89.35)), and immunosuppression (p = 0.01; Odds: 0.01 (0.0-0.54)) were independent related factors of mor-tality.

The rate of mortality due to FG and necrotizing fasciitis was 28.8%. Based on multivariateanalysis, the independent related factors of mortality were older age, lower haematocrit level and platelet count,and presence of immunosuppression.