The effect of intensity interval training and Tribulus terrestris supplementation on fibroblast growth factor 21 and adiponectin in obese women

Obesity leads to some chronic diseases. Adiponectin is an adipokine secreted by adipose tissue. Fibroblast 21 has anti-diabetic effects. On the other hand, Tribulus terrestris is a plant with anti-inflammatory and antioxidant activities. The aim of this study was to investigate the effect of intensity interval training (IIT) and consumption of T. terrestris supplement on fibroblast growth factor 21 and adiponectin in obese women.

In a quasi-experimental study, 40 obese women were randomly divided into four groups of 10 including IIT + placebo, T. terrestris supplement, IIT + T. terrestris supplement, and control. The training program was implemented for 8 weeks. The exercises were consisted of 7 repetitions of 20 seconds with an intensity of 85 to 100% of the stored heart rate. T. terrestris supplement was taken 500 mg twice per day for the training period.

IIT + T. terrestris increased serum levels of fibroblast 21 and adiponectin in volunteers. The difference between pre- and post-test fibroblast 21level was significant in IIT + placebo (p < 0.007), T. terrestris (p < 0.003), and IIT + T. terrestris (p < 0.0001) groups. The difference between pre- and post-test adiponectin level was also significant in IIT + placebo (p < 0.003), T. terrestris (p < 0.002) and IIT + T. terrestris (p < 0.0001). The IIT + T. terrestris group showed the most positive effect on increase of fibroblast growth factor 21 and adiponectin levels among the groups.

IIT along with consumption of T. terrestris supplement increases fibroblast growth factor 21 and adiponectin levels in obese women, and improves the obesity condition in these people.