The evaluation of of surface expression of platelet markers and left ventricle ejection fraction in patients with coronary artery disease

Surface expression of platelet markers enhanced during ischemic events and appear to play an important role in myocardial repair. Stromal cell-derived factor-1 (SDF-1) is one of these factors which its effects Mediated through CXCR4 and CXCR7 receptors. In our study we are going to determine the surface expressions of platelet markers and the changes of left ventricle ejection fraction in patients with coronary artery disease.

This descriptive cross-sectional study measured the superfi-cial expression of platelet indices (SDF-1R, CXCR4, and CXCR7) and its association with the changes of the left ventricle ejection fraction in patients with coronary artery disease who have referred to Taleghani Hospital, Tehran in 2017-2018.

Among all patients referred to Taleghani Hospital with symptoms of coronary artery disease, 57 patient had inclusion criteria. this study demonstrated that mean SDF1 and CXCR4 level were respectively 1.1 and 2.3 which there were significant difference between those with severe EF reduction comparing to the rest of the groups (respectively P<0.002 & P<0.004 ). The mean CXCR7 value of all patients was 3.5 (SD= 0.27) and showed a significant difference in patients with severe (6) and low (4.7) ejection fraction reductions compared to those with moderate (2.5) and normal (2.8) ejection fraction reductions (P<0.009).

Results from this study suggest that the level of surface expression of platelet markers (SDF-1, CXCR4, CXCR7) in patients with coronary artery disease who had severe LV dysfunction rise sharply compared to those with normal ejection fraction, and it can be, therefore, used as a factor to evaluate the level of damage caused by the coronary artery disease