Measurement of TGFB1 and JAK2 Polymorphism in the Blood Cells of Iranian women with Recurrent miscarriage

Recurrent miscarriage is two or more consecutive pregnancy losses before weeks 20. Different factors involved in recurrent abortion as a multifactorial disease. Genetic factors are one of the important factors associated with recurrent abortion. The goal of this article is to assess the association between single nucleotide polymorphisms of TGFB1 and JAK2 polymorphism and the recurrent miscarriage in Iranian women.

The study group was 30 women with recurrent miscarriages with unknown reason and the control groups consisted of 10 women with at least two successful pregnancies and no miscarriages. PCR was used to find the association between TGFB1 and JAK2 genes and recurrent miscarriages. Analysing performed with FinchTV software after data sequencing.

Our results provided evidence that TGFB1 polymorphisms influence the risk of recurrent abortion in the Iranian population however there is no correlation with JAK2 polymorphism and recurrent abortion.

This finding could help to prevent recurrent miscarriage in Iranian women.