The effect of six weeks of endurance training and Empagliflozin consumption on heart weight and electrical changes of the heart in male Wistar rat's diabetic with STZ

One risk factor for heart disease is type 2 diabetes, which plays a major role in mortality from cardiovascular disease. The aim of this study was to evaluate the effect of 6 weeks of endurance training and Empagliflozin consumption on some indicators of electrical heart activity in male diabetic rats.

  40 male Wistar rats (250±20 g) with an age range of 8-10 weeks were randomly divided into five groups: Diabetes Exercise (D + EX), Diabetes+Exercise+Empagliflozin (D+EX+EMP), Diabetes + Empagliflozin (D + EMP), control diabetes (DC) and control group (CONTROL) were divided and were kept in laboratory conditions. The (D + EX + EMP) and (D + EMP) groups also received empagliflozin by gavage for the same period and daily. 48 hours after the completion of the protocol, rats were anesthetized and an electrocardiogram (ECG) was recorded and then cardiac tissue was isolated and dissected. One-way ANOVA and Kruskal-Wallis statistical tests and Tukey, Games-Howell, Tamhane's T2, Dunn and Dunnett'sT3 post hoc tests were used for statistical analysis.

  Mean weight and blood glucose at the beginning of the study were not significantly different in the 5 groups, but after the end of the protocol, significant changes in weight, heart weight, serum glucose, QRS time, QT interval, QTc and ST height were observed in rats.

  The results of the present study showed that endurance exercise and the use of Empagliflozin can have a positive effect on the electrical conduction current of the heart of diabetic rats through reconstruction.