Correlation Between Ventricular Perfusion Ischemia and Left Ventricular Dyssynchrony in Phase Analysis by Gated SPECT MPI

The gated single-photon emission computed tomography (Gated SPECT), myocardial perfusion imaging (MPI) is one of the most accurate methods to evaluate the extent of myocardial ischemia. The present study aimed to assess the correlation between the severity of ischemia and left ventricular dyssynchrony in phase analysis with GATED SPECT MPI by comparing the indices of perfusion, function, and phase analysis in stress and rest phases.

This cross-sectional study was performed on patients referred for Gated SPECT MPI. Fifty-six patients with ischemic heart disease based on Gated SPECT MPI and invasive coronary angiography were included. Parameters regarding myocardial perfusion and function in stress and rest conditions and coronary vessel parameters were assessed. Phase analysis indices, including phase standard deviation (PSD), phase histogram bandwidth (PHB), and entropy, based on Gated SPECT MPI (with the QGS software) were also evaluated

Phase parameters, including PSD, PHB, and entropy, showed a good correlation with the severity of ischemia in stress conditions (P<0.05).

Scintigraphic indices of ischemia severity were highly correlated with phase analysis indices by Gated SPECT MPI. Therefore, an evaluation of these indices may accurately estimate systolic ventricular dyssynchrony, predict relative poor outcomes of cardiac ischemic events, and determine priorities for interventional cardiologists. (Iranian Heart Journal 2022; 23(1): 184-191)