The Effects of 8 Weeks Aerobic Exercise Training on Serum levels of Myonectine and Insulin Resistance in Obese and Overweight Women

Obesity is related to cardiovascular diseases, metabolic syndrome, diabetes, and insulin resistance in overweight and obese women. Myonectin is a myokine that is generally secreted from skeletal muscle and inversely associated with obesity. The aim of the present study was to investigate the effects of 8 weeks of aerobic training on serum levels of Myonectine and insulin resistance in obese and overweight women. In this study 21 obese women were allocated to exercise and control groups. Exercise training program comprised of 3 weekly sessions of 30 minutes of aerobic exercise training for 8 weeks that included running with 50 to 70 percent of maximum heart rate. 48 hours before and 48 hours after the last training session blood samples were collected and serum levels of Myonectine were measured. Analysis of covariance was used to assess differences between groups. Serum levels of Myonectine in the experimental group increased, but not significantly (p=0/08). and insulin resistance significantly decreased in the experimental group compared to the control group (p=0.006). According to the results, that is increase serum levels of myonectin and decrease insulin resistance, on the other hand, concerning myonectin role in increasing fatty acids uptake, exercise training can play important role in decreasing obesity-related diseases and metabolic syndrome that respect to present study, this effect partly related to Myonectin roles.