Acute response of exercise rehabilitation with electrical stimulation on serum levels antigen, carbohydrate 125 (CA-125) and cystatin (Cys-C) in myocardial infarction rats

Activation of inflammatory processes after a heart attack is necessary, but if it continues too long, it will facilitate the recurrence of myocardial infarction. Endurance training plays an important role in improving inflammation and the condition of heart attack patients. Accordingly, the present study aimed to investigate the acute response of sports rehabilitation with electrical stimulation on CA-125 and Cys-C in myocardial infarction rats.

In this experimental study with a control group of 50 Wistar rats (8 weeks old, weighing 220±30g) were randomly divided into 5 healthy groups: infarction, infarction-exercise rehabilitation, infarction-electrical stimulation and infarction-exercise rehabilitation-stimulation were electrically divided. Myocardial infarction was induced by subcutaneous injection of Isoproterenol (150 mg/kg) 24 hours apart in groups. The intervention groups underwent endurance training (treadmill at 20 m/min for 1 hour) and electrical stimulation (foot shock device with 0.5 mA for 20 minutes) for one session. Serum levels of CA-125 and Cys-C were assessed by ELISA immediately after the intervention. Data were analyzed by one-way ANOVA and Tukey post hoc at the significance level of P<0.05.

Induction of infarction significantly increases serum levels of CA-125 and Cys-C (P=0.0001). One session of electrical stimulation and exercise rehabilitation with electrical stimulation showed a significant decrease in serum CA-125 levels (P<0.05) but no significant changes were observed in serum Cys-C values (P˃0.05).

It seems that a session of electrical stimulation and exercise rehabilitation combined with electrical stimulation leads to the improvement of the inflammatory status of infarction patients.