Effect of Altered Calcium Metabolism on Orthodontic Tooth Movement: a Systematic Review

The aim of this study was to analyze and synthesize data from animal research on the impact of hormones and their synthetic derivatives on orthodontic tooth movement by altering calcium metabolism.

Eight databases were scanned electronically, followed by a manual search, until 27 February 2022. Animal experiments were chosen with control groups exploring the impact on orthodontic tooth movement with calcitonin, calcium, parathyroid hormone, teriparatide, and vitamin D. The reporting quality of primary studies was assessed using the CAMARADES tool. Data was collected from related studies and SYRCLE’s risk of bias tool was utilized to determine risk of bias.

Of the 2388 documents obtained in the search, 11 studies were included. The amount of orthodontic tooth movement reduced with the administration of calcitonin and calcium. However, with parathyroid hormone, teriparatide, and vitamin D, acceleration of tooth movement was noted. The results were statistically significant omitting three studies that assessed orthodontic tooth movement with calcium, vitamin D, and parathyroid hormone. Root resorption increased with calcium, vitamin D, PGE2, and a dose-dependent decrease was seen in higher doses of calcitonin. Bone mineral density improved with increased parathyroid hormone levels.

Vitamin D, their synthetic derivatives, and parathyroid hormone were found to increase orthodontic tooth movement. Calcitonin showed a dose dependent reduction in orthodontic tooth movement.