Echocardiographic increase of fractional shortening following experimental induction of hypertension in rats

This study was done to investigate the changes relation between the Fractional shortening obtained from echocardiographic findings following experimental hypertension induced in rats. Arterial hypertension is one of the most important diseases in human societies today. This disease affects the functional process of the heart. For this purpose, In the present study, The Fractional shortening following experimental hypertension in the heart of the studied rats was investigated. For this study 30 male Wistar rats were used. Echocardiography with physical restraint was performed on all studied rats and Fractional shortening was determined according to its formula. The animals under study were randomly divided into 3 groups. The first group was selected without surgery and the second group were induced hypertension and in the third group with operated control. The animals in the operated groups underwent abdominal surgery on the first day. To induce arterial hypertension, abdominal aortic stenosis was created above the renal arteries in the relevant group. Standard echocardiography was performed on days 7, 14 and 21. Then Fractional shortening was calculated. In this study, the mean of Fractional shortening in the hypertensive surgical group in day 14 was 40.42 ±0.18 Which showed the highest increase and it showed a significant difference on the same day in comparing whit control group (33.30 ± 0.15) and only surgery group (34.26 ± 0.21))p˂0.05). The present study showed that an increase in Fractional shortening index was observed following experimental arterial hypertension in rats.