The relationship between cardiorespiratory fitness with some biomarkers related to endothelial function and lipid profile of children with overweight and obesity

Sedentary lifestyle and obesity in children are important factors of many non-communicable diseases, including endothelial dysfunctions, and it has been suggested that high-intensity interval training (HIIT) may be very effective in improving some of the healthrelated metabolic variables. The aim of the present study was to examine the relationship between cardiorespiratory fitness and some biomarkers related to endothelial function and lipid profile of children with overweight and obesity. 

In the current experimental study, 24 overweight/obese volunteers (14±1year) with an average body mass index of 27.15±1.85 kg/m2 were divided into two equally high-intensity interval training (HIIT) and control groups. Subjects participated in an exercise interventionprogram for 12 weeks, three sessions per week. The association between cardiorespiratory fitness and measured variables was determined before and after exercise intervention. The linear regression analysis and Pearson correlation coefficient tests were used to analyze the data at a significance level of p <0.05.

The results revealed that cardiorespiratory fitness has the highest relationship between the levels of LDL (91%), miR-125a-5p (69.7%), Triglyceride (69.5%), body mass index (63.3%), HDL (62.9%), WHR (61.3%), cholesterol (50%), CRP (37%), and body weight (22.6%), respectively. Itwas also found that in the experimental group, changes in the levels of LDL (483.8%), triglyceride (170.6%), weight (135.4%), WHR (75.8%), body fat percentage (73.9%), and cardiovascular fitness (69.7%) have the highest relationship with hsa-miR-125a-5p levels, respectively. On the other hand, changes in body weight levels (%89.7), BMI (%61.1), LDL (%51.9), Cholesterol (%43.9), and cardiorespiratory fitness (%37.0) showed the highest relationship with CRP levels, respectively, following exercise training. 

Due to the relationship between cardiorespiratory fitness with levels of miR125a, C-reactive protein, and other measured biomarkers, the use of HIIT to improve cardiorespiratory fitness, control of overweight/obesity in adolescents, and the improvement of some biomarkers of endothelial function is recommended. It is also recommended that some anthropometric and metabolic variables that are associated with the endothelial disorder markers be considered so as to prevent this complication in adulthood.