Can Laparoscopic Cystectomy Improve Pregnancy Outcomes in Endometrioma? A Prospective Clinical Trial Study

The purpose of this prospective study was to compare the ovarian response and pregnancy outcomesin the infertile women with endometrioma undergoing assisted reproductive technologies (ART) in twogroups, who were underwent laparoscopic cystectomy and received gonadotropin releasing hormone-agonist(GnRH-agonist) and who only received GnRH-agonist without any surgery. In this prospective clinical trial study, 79 infertile women with asymptomatic endometriomascyst (2-6 cm) were enrolled and randomly assigned to two groups. First group underwent laparoscopiccystectomy and received GnRH-agonist. Second group only received GnRH-agonist without any surgery. Followingovulation induction, all patients underwent intracytoplasmic sperm injection (ICSI). Different parameterssuch as the number of retrieved oocytes and embryos; were made our outcomes that analyzed using SPSS. The pregnancy rate, chemical and clinical, and live birth rate were higher in the combined group,although these differences were not statistically significant (48.48% vs. 30.8%, P=0.12, 36.36% vs. 25.6%,P=0.32, 36.36% vs. 23.1%, P=0.29). The number of injections, antral follicles, retrieved oocytes, mature oocytes,total embryos, transferred embryos and duration of stimulation were similar in two groups. Laparoscopic cystectomy followed by receiving GnRH-agonist improves pregnancy outcomes in endometriomaprior to treatment with ART (registration number: IRCT201106116689N2).