Plasma Nesfatin Responses Following a Single Session of Interval Exercise in Young Men: Effects of Glucose, Sucrose and Fructose Intake

Nesfatin is a key regulator of glucose metabolism. The aim of this study was to identify the effect of glucose, sucrose and fructose intake following acute high intensity interval exercise (HIIE) on plasma levels of nesfatin, insulin and glucose in young males.

32 sedentary young males (21.9±2.3 yrs, 77.5±8.9 kg) were assigned into four groups (n= eight per group): glucose, sucrose, fructose and control or water groups. Subjects completed 4×4 min interval running with 90-95% maximal heart rate (HRmax) and 3 min active recovery with 65-70% HRmax between each interval. Blood samples were collected before, immediately after, 30, 60 and 90 minutes after exercise session. Immediately after the second blood sampling, carbohydrate liquids (1.5 g/kg glucose, fructose, sucrose and water) were consumed by the subjects in different groups. The data were analyzed using repeated measures ANOVA test and SPSS-24 software.

Results indicated that there was no significant difference between groups for Nesfatin (p=0.519) and glucose (p=0.062) levels; but, there was a significant difference between groups for insulin levels (p<0.001). Bonferroni multiple comparison corrections as a post hoc test showed a significant difference between water and glucose, water and sucrose, glucose and fructose, and sucrose and fructose groups in 30 and 60 minutes after HIIE (P<0.05).

with respect to the present study results, acute carbohydrate supplements (glucose, sucrose and fructose) don’t affect nesfatin response following exercise. Therefore, it seems that nesfatin doesn’t affect acute exercise-induced metabolic status response to different carbohydrate supplements in healthy subjects.