Separation of micro and nano particles using Induced Charge Electro Kinetic (ICEK) method in a rectangular channel

Exosomes are the main cause of cancer so separating them from blood can be effective in the diagnosis and management of diseases. The dimensions of the exosomes are very small, so separating them is very challenging. Ultracentrifugation is generally used to manipulate exosomes. The very high spin of centrifuges eliminates the exosomes and also it is expensive and requirement of specialized equipment. One of the most popular recent methods is using induce charge electrokinetic phenomena. The present study investigated the separation of biological particles (exosome) based on Induce Charge Electrokinetice (ICEK) methods using direct current (dc). The particle size range is between 1µm to 10nm. Problem geometry is a rectangular channel with a metal rectangular obstacle inside it. The results have shown that the strength of these vortices is large enough to trap the particles. In this study, a model for simultaneous separation of 5µm and 100 nm particles from each other with 100% efficiency is presented. The model presented in this study is a rectangular channel which has a rectangular barrier and simulated in the COMSOL limited element software