Therapeutic and Functional Application of Ceratonia Siliqua: Tradition Remedies and New Research Finding

Carob (Ceratonia siliqua L.) is an edible plant that is widely used in food industry and traditional medicine. This herb has pharmaceutical properties traditional medicine to treat cough, bronchitis, diarrhea, blood purifier and increased of appetite, lung swelling reliever, expectorant, improvement of lung cancer, cholesterol reducer and sexual enhancement. Today, in spite of confirmation its traditional benefits, the new therapeutic properties of this plant have beenknown and introduced.The aim of this review study was to determine therapeutic applications in traditional medicine, pharmacological and phytochemical properties, and new experimental studies of carob.

This study is a systematic review based on the PRISMA checklist with the keywords "Ceratonia siliqua", "therapeutic effect" and "experimental studies" without any time limit. 181 articles including review and original research related to its properties were extracted from PubMed, SID, Since Direct and Google search engines, and after a few steps of monitoring titles, reviewing abstracts, and deleting irrelevant items (botany and plant proliferations), 46 articles contains therapeutic application of carob in traditional and its experimental studies were finally selected and entered into the study.

In traditional medicine of different countries for carob, several therapeutic properties have been proposed, most of which are attributed to the antioxidant content, the presence of tannins and saponins. Carob has a variety of compounds with anti-diabetic, anti-proliferative and anti-cancer properties. Recently, a lot of research has been done to identify and confirm the medicinal properties of carob and its various properties, including the effect on reproductive parameters, antimicrobial and antidiabetic properties, liver and kidney protection and gametes cryoprotectant.

Carob has a variety and of biological properties. It is a valuable plant in medical research that helps improvement of health and prevention of some diseases.