Serum Levels of Vitamin D in Patients With Palindromic Rheumatism and its Relationship with Clinical Characteristics

Considering the clinical importance and remarkable prevalence of palindromic rheumatism and since there has been no study about serum vitamin D level in patients with palindromic rheumatism, therefore, present study designed to assess serum levels of vitamin D in patients with palindromic rheumatism and to analyze its relationship with clinical characteristics.   

In present study, 39 patients aged ≥ 16 years with diagnosis of palindromic rheumatism and 81 healthy individuals without any history of inflammatory rheumatic diseases were selected from rheumatology outpatient clinic of Tabriz University of Medical Sciences during 2020-2021. Clinical status of patients was assessed by a rheumatologist and frequency of attacks, duration of attacks, number of involved joints, and duration of symptoms were recorded. Serum 25(OH) vitamin D3 levels were measured using a kit.

Mean±SD serum 25(OH) vitamin D3 in patients and healthy subjects was 25.9±11.9 and 25.8±13.8 ng/mL, respectively (P=0.994). No significant relationship was observed between vitamin D deficiency and palindromic rheumatism (OR=0.39, 95%CI: 0.29-1.63, P=0.391). No significant correlation was observed between serum 25(OH)vitamin D3 and disease clinical characteristics including frequency of attacks, duration of attacks, number of involved joints, and duration of symptoms (P>0.05).  

There was no significant relationship between vitamin D deficiency and occurrence of palindromic rheumatism as well as between serum 25(OH) vitamin D3 and clinical characteristics. It is suggested that further studies with larger sample size are performed to achieve concise conclusion about preventive and therapeutic approach regarding the relation between vitamin D and clinical status in patients with palindromic rheumatism.