Vitamin D3 is well correlated with anti-Helicobacter pylori immunoglobulins and could be a well biomarker for immunity competence against the disease

Helicobacter pylori (HPY) provokes gastrointestinal disorders and gastric cancer. We supposed that HPY disrupts the 25‑OH‑Vitamin‑D3 (Vit.D3) absorption. We evaluated the association between Vit.D3 and anti‑HPY immunoglobulins (Igs) and the Vit.D3 potency as a predictive biomarker for HPY infection.

603 patients’ raw data were gathered from a private clinical laboratory. Anti‑HPY Igs including serum IgG, IgA, and IgM, in addition to HPY‑stool antigen, were assessed by the immunoassay methods. Vit.D3 was determined by high‑pressure liquid chromatography. Correlations, ordinal comparisons, cutoff points (COP), and odds ratio (OR) were estimated.

The age mean ± standard deviation was 39.83 ± 18.426 for female and 38.82 ± 16.937 for male participants (P = 0.521). Significant correlations existed after age and gender adjustment between Vit.D3 serum levels and the HPY IgG (R = 0.298) and IgA (R = 0.271) but not for IgM (R = −0.103). Approximately, 48% of males and 36% of females had insufficient/deficient Vit.D3 serum levels(male/female OR: 1.65; 1.16–2.33; P= 0.0051). After age and gender adjustment, the best COP of Vit.D3 to predict an HPY IgG‑positive patient was Vit.D3 >32.80 ng/mL with 66.23% diagnostic accuracy (DAAC), 30.43% specificity (SPC), and 90.41% sensitivity (SEN). For the HPY IgA, the values were Vit. D3 >37.83 ng/mL, DAAC = 60.45%, SPC = 58.82%, SEN = 64.20%. For HPY IgM, the values were Vit.D3 >37.32 ng/mL, DAAC = 58.97%, SPC = 57.33%, and SEN = 100%.

Vit.D3 had a good association with anti‑HPY Igs and may be a good biomarker for immunity competence against HPY infection if the patient’s age and gender are considered when interpreting the laboratory results.