STUDYING THE SIMULTANEOUS EFFECT OF COMBINED EXERCISES AND SUPPLEMENTATION OF MULBERRY LEAF EXTRACT ON SOME INFLAMMATORY BIOMARKERS EFFECTIVE IN THE PATHOGENESIS OF DIABETES AND HBA1C IN ELDERLY MEN WITH TYPE 2 DIABETES

Adipokines play an important role in inflammation and pathogenesis of diabetes. The aim of this study was to study the simultaneous effect of combined exercises (aerobic + resistance) and the consumption of mulberry leaf extract on the serum levels of galectin-3, apelin, and HbA1C in elderly men with type 2 diabetes

In this semi-experimental and single-blind research, 40 elderly men with the age range of 67.07 ± 7.48 years were purposefully selected and randomly divided into five equal groups (exercise, supplement, Supplement+exercise, placebo, and control). A daily dose of 1000 mg (two 500 mg capsules) of Mulberry leaf extract was used 3 times a day for 2 months. The exercise and exercise + supplement groups practiced for 8 weeks in 3 sessions, each week for 90 minutes. The studied variables were measured 24 hours before and 48 hours after the intervention period.

Galectin-3, apelin, and HbA1C levels in the post-test of the exercise, exercise+supplement, and supplement groups were significantly reduced compared to the pre-test (P<0.05). Also, the results of covariance analysis showed that the levels of galectin-3, apelin, and HbA1C in the exercise, exercise+supplement and supplement groups were significantly reduced compared to the placebo and control groups (P<0.05).

It seems that combined exercises and consumption of Mulberry leaf extract can be effective in reducing inflammatory biomarkers effective in the pathogenesis of diabetes in the elderly with type 2 diabetes. However, supplementing with combined exercise has the greatest effect on controlling these inflammatory markers.