Evaluation of Laboratory Diagnostic Markers in Patients with Hypertension

Hypertension is growing as a running title public health problem. It is one of the most important risk factors for various diseases including cardiovascular disease. The study of laboratory markers and early detection of complications can play an effective role in controlling the disease.

The present study was a descriptive-analytical cross-sectional one that was performed from March 21, 2020, to March 19, 2021, on patients referred to Abadan and Khorramshahr educational hospitals with hypertension. Information on age, sex, and laboratory diagnostic factors of patients with hypertension admitted to HIS were received. Data were analyzed using STATA software.

The study population involved 1505 patients with hypertension admitted to Abadan and Khorramshahr educational hospitals; there were 487 males (32%) and 1018 females (68%). The average age of the patients was 61 (SD: 12). The highest frequency of patients with hypertension was in the age group of 64-55 years with afrequency of 420 (27.9%). The results showed that the mean of creatinine was higher than normal. The mean of CK-MB and INR was slightly higher than normal. The two sexes were significantly different in terms of the means of CK-MB, AST, ALT, Cr, Na, MCHC, HCT, HB, and RBC. According to the unadjusted and multiple logistic regression analysis, each 1 unit increase in BUN and K+ was associated with an increase in the odds of abnormal creatinine. Each 1 unit increase in RBC, HB, HCT, MCH, and MCHC was associated with a decrease in the odds of abnormal creatinine, and each 1 unit increase in PT was associated with an increase in the odds of abnormal creatinine.

The results of the present study showed that some laboratory markers in patients with hypertension were above the normal range including renal, cardiac, and coagulation diagnostic factors and some of which depend on age and sex; thus, it is important to pay attention to these markers in controlling high blood pressure in these patients. Futurestudies are warranted to examine the issue further