Preparation and Characterization of Magnetic Gelatin-Polyvinyl Alcohol Hydrogel for using in the Release of Furosemide Drug

The magnetic  gelatin-polyvinylalcohol hydrogel  was prepared using K2S2O8 in aqueous media in the  presence  of  N,N′-methylenebisacrylamide,  and Fe3O4 nanoparticles.  The magnetic  gelatinpolyvinylalcohol (Fe3O4/PVA-gelatin) hydrogel was characterized by FT-IR, SEM, and EDX. Also, magnetic  characterization  of  the  synthesized Fe3O4/PVA-gelatin  hydrogel  was  specified  by a vibrating sample magnetometer (VSM). Then, the loading and release of the furosemide drug wereinvestigated  using  magnetic gelatin-polyvinylalcohol  hydrogel. The  FT-IR  results  confirmed  the formation of gelatin-polyvinyl alcohol magnetic hydrogel. The effects of temperature and pH on the loading and release of furosemide drug in gelatin-polyvinylalcohol magnetic hydrogel were studied. The gelatin-PVA magnetic hydrogel is sensitive to pH and temperature and provides the controlled release of furosemide. The results showed that the highest loading of the drug was achieved at room temperature after 6 hours. Also, the highest drug release was observed after 4 hours at 40 °C in pH = 7.