EVALUATION OF THE RELATIONSHIP BETWEEN THE PREVALENCE OF HELICOBACTER PYLORI IN THE GALLBLADDER MUCOSA AND CLINICAL SYMPTOMS IN PATIENTS WITH SYMPTOMATIC CHOLELITHIASIS
gallstone is a common and frequent disease of the digestive system. Bacterial infections may also contribute to the formation and symptoms of gallstones. One of the prominent bacteria in this field is Helicobacter pylori. This study was conducted with the aim of investigating the relationship between the prevalence of Helicobacter pylori in the gallbladder mucosa and its clinical symptoms in the patients with symptomatic cholelithiasis who underwent surgery.
In this cohort study, 60 patients who underwent surgery for symptomatic cholelithiasis in the fourth quarter of 2018 were included in the study. Patients were examined in terms of demographic characteristics and clinical symptoms including preoperative symptoms. Hematoxylin-eosin staining was performed for histological examination, and Giemsa staining was performed for Helicobacter pylori examination. In the microscopic study, the stained slides were studied with a maximum magnification of 40 or 100 for the presence or absence of Helicobacter pylori.
In this study, 13 people (21.7%) were male and 47 people (78.7%) were female. The average age of the patients was 47.61 ± 13.51 years. In 17 people (28.3%), the gallbladder mucosa was positive for Helicobacter pylori. The most common clinical symptoms in Helicobacter pylori positive patients were: epigastric pain in 70.6%, nausea and vomiting in 52.9%, loss of appetite in 23.5%, pain between the two shoulder blades in 23.5%, and fever in 11.8 percent. In this study, no significant relationship was found between the clinical symptoms of cholelithiasis and the presence of Helicobacter pylori in the gallbladder mucosa. Also, no significant relationship was found between the presence of this bacteria in the gallbladder mucosa and the age and sex of the patients (P<0.05).
The results of this study showed that there is no significant relationship between the clinical symptoms of cholelithiasis and the presence of Helicobacter pylori in the gallbladder mucosa in the studied groups. Also, there is no relationship between the presence of this bacteria in the gallbladder mucosa and the age and sex of the patients.
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