Interactive Effect of Grape Seed Nanoparticle Extract and Resistance Training on Antioxidant System Function in Myocardial Infarction Rat Model

 The use of herbal supplements and exercise to treat chronic diseases and metabolic disorders is a common practice.

 This study aimed to investigate the effect of eight weeks of grape seed nanoparticle extract and resistance training on SOD, MDA, and NRF-1 expression in the myocardial infarction rat model.

 In this experimental trial, 25 Wistar rats were randomly divided into five groups: (1) control, (2) MI, (3) RT + MI, (4) GS + MI, and (5) RT + MI + GS. Resistance training was performed for eight weeks and five sessions per week. Also, 150 mg of grape seed extract was gavage daily. One-way analysis of variance and the Tukey test was used to compare groups at the P ≤ 0.05.

 Resistance training with grape seed significantly increased NRF-1 gene expression (P = 0.001) and SOD (P = 0.01) compared to MI grope. While resistance training with grape seed significantly reduced MDA compared to the MI group (P = 0.01).

 It seems that resistance training with grape seed consumption has a more positive effect on increasing NRF-1 gene expression and improving the antioxidant system in the heart tissues of rats with myocardial infarction rather than using each alone.