Designed a Spectrophotometric Method for the Determination of Acetaminophen Drug Residual after Consumption in Human Fluid Samples by Using Chitosan-Capped Gold Nanoparticles

In this study, we used a prepared from chitosan-capped AuNPs for the determination of trace amount acetaminophen drug in various matrices such human fluids by kinetic spectrophotometric method. The calibration curve was linear in the range of (0.05 to 10.0 µg L−1). The standard deviation of (1.9%), and detection limit of the method (0.05 µg L−1 in time 6 min, 325 nm) were obtained for Sensor level response chitosan-capped AuNPs with (95%) confidence evaluated. Observed outcomes confirmed the suitability recovery, and a very low detection limit for measuring the acetaminophen drug. The method introduced to measure acetaminophen drug in real samples such as urine, and blood can be used for other drugs, and hospital samples.