Apoptotic changes of cardiac tissue after HIIT and thyme honey in type 2 diabetic rats

  The aim of the present was to Study of apoptotic changes of caspase 3 and 9 proteins and cytochrome c of heart tissue after High intensity interval training (HIIT) and thyme honey in type 2 diabetic rats.

The statistical population consisted of male diabetic rats that 20 rats were divided into 4 groups: control, HIIT, thyme honey, HIIT-thyme honey. The training protocol was implemented as eight weeks of HIIT and five sessions per week. Insulin was measured using the insulin kit and the ELISA method and the expression of caspase 3, caspase 9 and cytochrome-C genes by RT-PCR method. Statistical analysis was performed using SPSS version 22 software and two-factor analysis of variance and determination of effect size and Bonferroni post hoc.

compared to the control group, HIIT led to a significant decrease in glucose (0.0001) and insulin resistance index (0.001). HIIT increased the expression of caspase 9 genes (0.001) in cardiac cells compared to the control group.

It can be concluded that performing HIIT by diabetic patients can lead to an increase in the apoptotic factor. Therefore, the use of more moderated intensities, as well as the use of substances with antioxidant and anti-inflammatory properties, such as honey, along with exercise can be useful.