Effect of Four Weeks of Aerobic Training with Beetroot Supplementation on Some Kidney Damage Biomarkers in Elderly Diabetic Rats

Uncontrolled diabetes often leads to complications such as kidney diseases. This study aimed to investigate the effect of four weeks of aerobic training with beetroot supplementation on some kidney damage biomarkers in elderly diabetic rats.

In this experimental-fundamental study, 32 diabetic rats were divided into groups (1) diabetic control, (2) aerobic training, (3) beetroot supplement, (4) aerobic training and beetroot supplement. Moreover, eight healthy rats were considered as a healthy control group. Groups 2 and 4 were trained at a maximum speed for four weeks, and rats in groups 3 and 4 received 10 mg/kg beetroot juice daily for four weeks. One-way analysis of variance and Tukey's post hoc test were used to examine the differences between and within groups.

The findings of this study showed Blood Urea Nitrogen, creatinine and albumin values ​​in the diabetic control group were significantly higher than the healthy control group (P=0.001). Additionally, the values ​​of BUN, creatinine and albumin in the training + beetroot group were significantly lower than the diabetic control group (P=0.05). The BUN, creatinine and albumin tests have favorable diagnostic value in diagnosing kidney disease following beetroot consumption and aerobic exercise in diabetic rats (P=0.05).

It seems that training and beetroot supplements alone could improve kidney damage biomarkers.