Solid phase extraction based on magnetic graphene oxide nanocomposite and ion mobility spectrometry for determination of bupropion

In this paper, a solid phase extraction based on magnetic graphene oxide nanocomposite has been introduced for the quantitative extraction of bupropion. The characterization and structural studies for the nanocomposite were carried out by fourier transform infrared spectrometry, scanning electron microscopy and X–ray diffraction techniques. Ion mobility spectrometry as a sensitive, rapid and simple method was applied for the determination of bupropion. The effect of experimental parameters (including desorption solvent: type and volume, adsorbent amount, pH, temperature and time extraction, and initial solution volume) on the extraction efficiency of the proposed method was investigated. Under optimum conditions, the calibration curves were linear in the two ranges of 4–10 and 10–24 ng with coefficients of determination R2≥ 0.98. The relative standard deviation was 5% and also the limits of detection and quantification were 0.66 and 2.20 ng, respectively. The proposed method was applied for the different brand tablets with various doses of bupropion which the satisfactory quantitative results were obtained (recovery: 88.0–92.0%).