Assessing etiopathological factors underlying Multiple Sclerosis disease from epigenetics and psychological perspectives

Multiple Sclerosis (MS) in referred to as the most prevalent autoimmune disease throughout the world. Besides it is also known as a chronic inflammatory disease which affect brain as well as spinal cord. Neurological and psychological symptoms (neuropsychotic) have been reported in more than 60% of MS patients that relates to medication as well as life quality. The depression particularly arises amongst afflicted individuals. The life-long epidemy of depression is estimated to affect around 50% of MS patients.

In the current review study, published research articles about the genetic, psychological and other environmental factors underlying MS manifestation were searched and investigated through reputed medical databases like NCBI, PubMed, MEDLINE etc.

MS is an autoimmune disease whose sign and symptom include vision deficiency, fatigue, muscular system disfunction and spasm in different levels. The severity of these symptoms are not equal in all patients and thus complicating the MS diagnosis.

MS is an inflammatory disease of the nervous system which is accompanied by the inflammation and destruction of myelin sheath. The immune system invades the central nervous system in this disease that is followed by destruction of  neurons which leads to signaling disorder. Damages in axons are also another consequence of MS, which is the main cause of inabilities in the disease.