Chemiluminescence determination of pethidine hydrochloride and thebaine alkaloides

The aim of this work was finding new flurescent dyes as sensitizers for chemiluminescence (CL) determination some of narcotics. In this way 6 different dyes incloding rhodamine 6G, brilliant blue, orange G, chromatrope, eosin Y and [Ru(phen)3]2+ and 14 drugs incloding pethidine hydrochloride, thebaine, dextromethorphan, acetaminophen, codeine, oxymorphone, oxycodone, morphine, pholcodine, naltrexone, buprenorphine, methadone, tramadol, diphenoxylate were investigated. In the preliminary experiments, we found that pethidine hydrochloride in CL system of [Ru(phen)3]2+- Ce(IV) and thebaine in CL system of rhodamine 6G- Ce(IV) could be determined. After optimizing the important variables, linear dynamic range for pethidine hydrochloride and thebaine were 5.6×10-7 to 1.4×10-3 mol L-1 and 1.0×10-5 to 4.0×10-4 mol L-1 and limit of detection were 7.1×10-8 mol L-1 and 4.3×10-6 mol L-1, respectively. The percent of relative standard deviation for pethidine hydrochloride and thebaine were 5.7 and 4.0%, respectively.