Platelet-rich plasma alleviates skin photoaging and oxidative stress in rats by regulating autophagy and inhibiting the NLRP 3 inflammasome pathway

Ultraviolet radiation is the main cause of photoaging, which can induce oxidative stress and cellular senescence in the skin. It has been demonstrated that platelet-rich plasma (PRP) can significantly improve skin photoaging. However, the mechanism by which PRP improves photoaging remains unclear.

In this study, UVA-induced SD rats were used as a skin photoaging model and administered with PRP treatment, aiming to elucidate the potential mechanism of its protection against photoaging.

They showed that PRP injection on the back of rats improved skin photoaging, oxidative stress, and inflammation, and inhibited skin cell apoptosis. In addition, RPR activated autophagy to inhibit NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome signaling pathway-related proteins.

Our experimental results suggest that PRP plays an anti-UVA photoaging role by inhibiting autophagy and NLRP3 signaling pathways. Our study is the first to suggest that PRP anti-skin photoaging is associated with autophagy and NLRP3, providing a potential therapeutic approach for skin photoaging.