Validity and Reliability of The Persian Version of Uterine Fibroid Symptom and Health-Related Quality of Life Questionnaire: A Psychometric Study

Women with uterine fibroids (UFs) experience many clinical manifestations that affect their quality oflife (QOL). The Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) questionnaire is an Englishinstrument specifically designed to assess fibroid-related symptoms and their impact on QOL. This study aims toinvestigate the reliability and validity of the Persian version of the UFS-QOL questionnaire in Iranian women with UF. In this psychometric study, women with UFs who presented to Imam Hossein Hospital(Tehran, Iran) between August 2022 and January 2023 were enrolled in this study. A forward-backward approachwas applied to translate the UFS-QOL questionnaire into Persian. The reliability of the UFS-QOL questionnaire wasassessed by internal consistency and test-retest correlation. Confirmatory factor analysis (CFA) was used to assessconvergent validity between items and subscales of the UFS-QOL questionnaire. Pearson’s correlation coefficient wasused to assess convergence validity between subscales of the UFS-QOL and the World Health Organization Qualityof Life Brief Version 26 questionnaire (WHOQOL-BREF-26). Overall, we assessed 226 women with UFs. All subscales of the UFS-QOL questionnaire had acceptableinternal consistency (Cronbach’s alpha>0.7). Test-retest analysis indicated significant positive correlations betweentwo measurements of all subscales of the UFS-QOL questionnaire: symptom severity (P<0.001), concern (P<0.001),activities (P<0.001), energy/mood (P<0.001), control (P<0.001), self-consciousness (P=0.002), and sexual function(P<0.001). The Kaiser-Meyer-Olkin (KMO) measure value was 0.920, and the result of Bartlett’s test of sphericitywas significant (P<0.001). CFA identified six factors for the health-related QOL (HRQL) questionnaire, which explained73.827% of the total variation. Most subscales of the UFS-QOL questionnaire correlated with domains of theWHOQOL-BREF-26 questionnaire (P<0.05). The Persian version of the UFS-QOL questionnaire is a valid and reliable instrument to evaluate UFrelatedsymptoms and QOL among Iranian women.