PROBIOTIC BACILLUS COAGULANS: A RAY OF HOPE FOR BETTER HEALTH

Dear Editor, Live microorganisms called probiotics have beneficial effects on the host's health (1). Probiotic Bacillus coagulan has received more attention than others. Hammer first isolated it from contaminated canned milk in 1915 (2). In research, this probiotic has demonstrated unique properties and benefits. 1.Resistance: This probiotic is very resistant to techniques for food preparation, like boiling and cooking, so it is a good choice for use in food companies (3). Also, this probiotic was found to not adversely affect the nutritional and sensory properties of the product (4). 2.Genome: One of the essential advantages of this type of probiotic is that it is almost impossible to transmit antibiotic resistance genes to the next generation, and they can recover the genes if at risk (5). 3. Microbiota: Many diseases are associated with an imbalance in the Microbiota, so balance helps maintain health and treat disease (6). Probiotics have been shown by many studies to be essential in maintaining human immunological homeostasis. It also received much attention in this field because of its strong regulatory effect on the host microbiota and immune response, with little concern for harm or risk from ingestion (7). 4. reactive oxygen species(ROS): This Probiotic, through different methods, can increase human immunity, including the ability to produce a variety of active radicals (8). 5. Immunity and Inflammation: Ingestion of Bacillus coagulans can markedly regulate inflammatory immune factors such as interferon-gamma (IFNγ), interleukin (IL), and tumor necrosis factor (TNF) without altering natural cytokines. This probiotic can produce immune-activating cytokines, anti-inflammatory, chemokines, and growth factors (7). 6. PH: Various research shows that probiotics positively affect natural flora, but they are highly sensitive to acidic environments, while some probiotic species have high resistance in these conditions (9, 10). And even with a decreased pH, it can make the environment unfavorable for other microorganisms (11). Finally, due to the extensive and beneficial effects of this probiotic and its effect on the oxidative stress process, it seems that the use of its products can affect the prevention, improvement, treatment and rehabilitation of many chronic diseases. Also according to The significant effect of Bacillus coagulan on the host's immune system and according to some evidence supporting the various effects of this probiotic may be useful in the management and reduction of human diseases.