Preparation and in Vitro Property Research of Cholic Acid Nanoparticles with Dual Functions of Hemostasis and Antibacterial
Jin Ma , Cong Wang , Tieying Yin , Yang Jiang , Wanjun Yu , Xiaoyu Zhang , et al.
Hemorrhage control and anti-infection play a crucial role in promoting wound healing in trauma-related injuries.
This study aimed to prepare nanoparticles with dual functions of hemostasis and antibacterial properties.
The dual-functional nanoparticles (CDCA-PLL NPs) were developed using a self-assembly method based on the electrostatic forces between Poly-L-lysine (PLL) and Chenodeoxycholic acid (CDCA). The physicochemical properties, hemostatic properties, and antibacterial activities were investigated.
The prepared nanoparticles displayed a spherical structure, exhibiting a high drug loading capacity, encapsulation efficiency, and good stability. The CDCA-PLL NPs could reduce the hemolysis caused by PLL and promote the proliferation of human fibroblasts, indicating excellent biosafety. Moreover, CDCA-PLL NPs demonstrated a shorter in vivo hemostasis time and reduced blood loss in mouse tail vein hemorrhage, femoral vein hemorrhage, femoral artery hemorrhage, and liver hemorrhage models. Also, CDCA-PLL NPs showed excellent antibacterial efficacy against E. coli and S. aureus.
CDCA-PLL NPs have great potential to be extensively applied as a hemostatic and antibacterial agent in various clinical conditions.
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