The association of lncRNA H19 rs217727 polymorphism with oral lichen planus in Shiraz, Iran

This study aimed to assess the single nucleotide polymorphisms (SNPs) of lncRNA (long non-coding RNA) H19 rs217727 in patients with oral lichen planus (OLP) compared to controls.

We collected 270 DNA samples of OLP cases and healthy individuals. We used the ARMS-PCR tetra primer for DNA genotyping and applied specific primer pairs.

The prevalence of the rs217727 C allele was lower in OLP cases than in healthy subjects (P = 0.005). The prevalence of TT genotypes of H19 rs217727 was greater in OLP patients compared with healthy subjects (5.71% vs 1.5%). Also, the TT genotype in the codominant model was associated with a 5.15-fold higher risk of OLP (P = 0.02). In the dominant model, the CT+TT genotypes were associated with a 2.09-fold greater risk of OLP (P = 0.007). The H19 rs217727 polymorphism was linked to a 3.95-fold greater risk of OLP in the recessive model (P = 0.05) (TT vs. CC+CT).Also, in the over-dominant model, the CT genotypes were related to a 1.78-fold greater risk of OLP (P = 0.03).

This study demonstrated a significant link between lncRNA H19 polymorphism and OLP lesions. Further studies on larger populations are necessary to confirm this relationship.