Correlation between arterial stiffness changes following glucose ingestion and aerobic exercise with baseline levels of blood sugar factors (FBS) and Malondialdehyde (MDA) in inactive women

The purpose of this research was to investigate the relationship between basal levels of malondialdehyde (MDA) and fasting blood glucose (FBS) with arterial stiffness indices (including cardiovascular-ankle vascular index (CAVI) and ankle-brachial index (ABI)) following glucose ingestion and aerobic exercise.

This semi-experimental research was conducted on 40 inactive women subjects in the age group of 20 to 45 years, Shahrood city. After 12 hours of fasting, FBS and MDA were measured. Then the measurements of weight, height, body composition and arterial stiffness (CAVI and ABI) were taken at baseline and response; 30 minutes, acute endurance activity with 65% maximum heart rate was performed on the treadmill. Consumption of 75 grams of glucose in 225 ml of water was done after 30 minutes of finishing the activity, and after that, another hour of inactive rest was done, and at the end, arterial stiffness and blood sugar were measured again.

There is a significant relationship between the baseline levels of MDA and FBS with the baseline levels of CAVI (p=0.001), but there was no significant relationship between these baseline levels of these two variables with changes in CAVI after exercise and glucose ingestion (p>0.05). ABI was also significantly related to baseline levels of MDA and FBS in both baseline (p=0.001) and response (p=0.003) levels.

In general, it can be concluded that baseline arterial stiffness is related to baseline levels of MDA and FBS, but in the face of conditions disturbing homeostasis such as exercise and glucose ingestion, only the changes in peripheral arterial stiffness (ABI) are related to these cases.